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Suppressive Myeloid Cells Are a Hallmark of Severe COVID-19
Cell, September. 182 (6): 1419–1440.e23
Schulte-Schrepping, Jonas, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, et al. 2020.
Alterations of Multiple Alveolar Macrophage States in Chronic Obstructive Pulmonary Disease
bioRxiv, May. Cold Spring Harbor Laboratory, 2020.05.28.121541
Kevin Baßler, Wataru Fujii, Theodore S. Kapellos, Arik Horne, Benedikt Reiz, Erika Dudkin, Malte Lücken, et al. 2020.
Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics
iScience 23 (1): 100780
Stefanie Warnat-Herresthal, Konstantinos Perrakis, Bernd Taschler, Matthias Becker, Kevin Baßler, Marc Beyer, Patrick Günther, et al. 2020.
A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space
bioRxiv, June. Cold Spring Harbor Laboratory, 658179
Patrick Günther, Branko Cirovic, Kevin Baßler, Kristian Händler, Matthias Becker, et al. 2019.
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. Epub 2019 Nov 14. PubMed PMID: 31735593; PubMed Central PMCID: PMC6944439.
Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD.
Memory-Driven Computing Accelerates Genomic Data Processing
bioRxiv, January. Cold Spring Harbor Laboratory, 519579
Matthias Becker, Milind Chabbi, Stefanie Warnat-Herresthal, Kathrin Klee, Jonas Schulte-Schrepping, Pawel Biernat, Patrick Günther, Kevin Baßler, et al. 2019.
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Cell 2018 Jan 11;172(1-2):162-175.e14. PubMed PMID: 29328911; PubMed Central PMCID: PMC6324559.
Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.
Mapping the human DC lineage through the integration of high-dimensional techniques
Science. 2017 Jun 9;356(6342). pii: eaag3009. Epub 2017 May 4. PubMed PMID: 28473638.
See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Rénia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F.
Specification of tissue-resident macrophages during organogenesis
Science. 2016 Sep 9;353(6304). pii: aaf4238. Epub 2016 Aug 4. PubMed PMID: 27492475; PubMed Central PMCID: PMC5066309.
Mass E, Ballesteros I, Farlik M, Halbritter F, Günther P, Crozet L, Jacome-Galarza CE, Händler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M, Bock C, Geissmann F.
Neutrophils in COVID-19
Front. Immunol., March,
Nico Reusch, Elena De Domenico, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Kevin Baßler, Joachim L. Schultze, and Anna C. Aschenbrenner 2021.
Mind the Map: Technology Shapes the Myeloid Cell Space
Front Immunol. 2019 Oct 4; 10:2287. eCollection 2019. Review. PubMed PMID: 31636632; PubMed Central PMCID: PMC6787770.
Günther P, Schultze JL.
The Myeloid Cell Compartment—Cell by Cell
Annual Review of Immunology 37 (1): 269–93
Kevin Baßler, Jonas Schulte-Schrepping, Stefanie Warnat-Herresthal, Anna C. Aschenbrenner, and Joachim L. Schultze. 2019.
A bioinformatic toolkit for single-cell mRNA analysis
Methods in Molecular Biology, 1979:433–55. Humana Press Inc.
Kevin Baßler, Patrick Günther, Jonas Schulte-Schrepping, Matthias Becker, and Paweł Biernat. 2019.
Dysregulated Functions of Lung Macrophage Populations in COPD
Journal of Immunology, Research 2018 (February). Hindawi: 1–19
Theodore S. Kapellos, Kevin Baßler, Anna C. Aschenbrenner, Wataru Fujii, and Joachim L. Schultze. 2018.
Navigating Disease Phenotypes – A Multidimensional Single-Cell Resolution Compass Leads the Way
Current Opinion in Systems Biology 3 (June). Elsevier: 147–53
Marc Beyer, Kristian Händler, Patrick Günther, Kevin Baßler, Thomas Ulas, Matthias Becker, Kathrin Klee, Joachim L. Schultze, and Andreas Schlitzer. 2017.
A Cross-Species Approach to Identify Transcriptional Regulators Exemplified for Dnajc22 and Hnf4a
Scientific Reports, no. May. Springer US: 1–15
Anna C. Aschenbrenner, Kevin Baßler, Mirco Brondolin, Lorenzo Bonaguro, Pilar Carrera, Kathrin Klee, Thomas Ulas, Joachim L. Schultze, and Michael Hoch. 2017.
Accelerated Genomics Data Processing Using Memory-Driven Computing
In Proceedings – 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019, 1850–55. Institute of Electrical and Electronics Engineers Inc.
Matthias Becker, Hartmut Schultze, Thomas Ulas, Sharad Singhal, Joachim L. Schultze, Milind Chabbi, Stefanie Warnat-Herresthal, […], Kevin Baßler, et al. 2019.
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction
Immunity 50 (5): 1232-1248.e14
Lisa Schmidleithner, Yasser Thabet, Eva Schönfeld, Maren Köhne, Daniel Sommer, Zeinab Abdullah, Timothy Sadlon, […], Kevin Baßler, et al. 2019.
Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells
Blood 2018: blood-2018-06-856203
Eleni Kabrani, Van Trung Chu, Evangelia Tasouri, Thomas Sommermann, Kevin Baßler, Thomas Ulas, Thorsten Zenz, et al. 2018.
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2
Immunity 47 (6): 1051–1066.e12
Jil Sander, Susanne V. Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, […], Kevin Baßler, et al. 2017.
Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics.
Dec 18. PubMed PMID: 31918046 Form; PubMed Central PMCID: PMC6992905.
Warnat-Herresthal S, Perrakis K, Taschler B, Becker M, Baßler K, Beyer M, Günther P, Schulte-Schrepping J, Seep L, Klee K, Ulas T, Haferlach T, Mukherjee S, Schultze JL. iScience. 2020 Jan 24;23(1):100780. Epub 2019
Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor.
Stem Cell Reports. 2016 Apr 12;6(4):539-551. Epub 2016 Mar 24. PubMed PMID: 27052315 Form; PubMed Central PMCID: PMC4834053.
Shahbazi E, Moradi S, Nemati S, Satarian L, Basiri M, Gourabi H, Zare Mehrjardi N, Günther P, Lampert A, Händler K, Hatay FF, Schmidt D, Molcanyi M, Hescheler J, Schultze JL, Saric T, Baharvand H.
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin.
Cell Res. 2016 Feb;26(2):151-70. Epub 2016 Jan 5. PubMed PMID: 26729620 Form; PubMed Central PMCID: PMC4746609.
Schmidt SV, Krebs W, Ulas T, Xue J, Baßler K, Günther P, Hardt AL, Schultze H, Sander J, Klee K, Theis H, Kraut M, Beyer M, Schultze JL.
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.
Science. 2015 Nov 20;350(6263):972-8. Epub 2015 Oct 29. PubMed PMID: 26516201
Vacchelli E, Ma Y, Baracco EE, Sistigu A, Enot DP, Pietrocola F, Yang H, Adjemian S, Chaba K, Semeraro M, Signore M, De Ninno A, Lucarini V, Peschiaroli F, Businaro L, Gerardino A, Manic G, Ulas T, Günther P, Schultze JL, Kepp O, Stoll G, Lefebvre C, Mulot C, Castoldi F, Rusakiewicz S, Ladoire S, Apetoh L, Bravo-San Pedro JM, Lucattelli M, Delarasse C, Boige V, Ducreux M, Delaloge S, Borg C, André F, Schiavoni G, Vitale I, Laurent-Puig P, Mattei F, Zitvogel L, Kroemer G.
Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.
Sci Rep. 2015 Jun 9;5:11126. PubMed PMID: 26057209 Form; PubMed Central PMCID: PMC4460895.
Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Cell . 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27.
Daniel Wendisch, Oliver Dietrich, Tommaso Mari, Saskia von Stillfried, Ignacio L Ibarra, Mirja Mittermaier, Christin Mache 7, Robert Lorenz Chua, Rainer Knoll, Sara Timm, Sophia Brumhard, Tobias Krammer, Henrik Zauber 3, Anna Luisa Hiller 1, Anna Pascual-Reguant 11, Ronja Mothes 12, Roman David Bülow 4, Jessica Schulze 7, Alexander M Leipold 2, Sonja Djudjaj 4, Florian Erhard 13, Robert Geffers 14, Fabian Pott 15, Julia Kazmierski 15, Josefine Radke 16, Panagiotis Pergantis 1, Kevin Baßler 9, Claudia Conrad 1, Anna C Aschenbrenner 17, Birgit Sawitzki 18, Markus Landthaler 19, Emanuel Wyler 19, David Horst 20; Deutsche COVID-19 OMICS Initiative (DeCOI); Stefan Hippenstiel 21, Andreas Hocke 21, Frank L Heppner 22, Alexander Uhrig 1, Carmen Garcia 1, Felix Machleidt 1, Susanne Herold 23, Sefer Elezkurtaj 20, Charlotte Thibeault 1, Martin Witzenrath 21, Clément Cochain 24, Norbert Suttorp 21, Christian Drosten 25, Christine Goffinet 15, Florian Kurth 26, Joachim L Schultze, Helena Radbruch, Matthias Ochs, Roland Eils, Holger Müller-Redetzky, Anja E Hauser, Malte D Luecken, Fabian J Theis, Christian Conrad, Thorsten Wolff, Peter Boor, Matthias Selbach, Antoine-Emmanuel Saliba, Leif Erik San
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5.
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI).
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
Nat Commun . 2022 Mar 14;13(1):1303. doi: 10.1038/s41467-022-28809-4.
Günes Günsel G, Conlon TM, Jeridi A, Kim R, Ertüz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar Ö, Konyalilar N, Kanashova T, Rodius S, Ballester-López C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Königshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AÖ.